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When local vasoconstriction becomes excessive, the body responds by releasing specific neuropeptides (CGRP, substance P, and neurokinin A), causing a rebound dilation in the segments of these overly constricted arteries. This sudden rebound dilation is a natural defensive mechanism of our body to compensate for extended periods of blood deprivation. These arteries are wrapped with sensitive pain receptors and are being activated due to dilation of arteries, thus causing migraine pain. The migraine pain is often localized because over-dilation occurs in a limited area. Blue Opal Scanning

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